For research use only. Not for therapeutic Use.
QCP01 is a new imaging agent for cancer study.
| Catalog Number | I035303 |
| Synonyms | QCP01; QCP-01; QCP 01; |
| Molecular Formula | C66H75N7O17S4 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 1-(6-((3-((4-((2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)amino)-6-oxohexyl)-2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfo-1-(4-sulfobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-3H-indol-1-ium-5-sulfonate |
| InChI | InChI=1S/C66H75N7O17S4/c1-65(2)54-40-50(93(83,84)85)24-27-57(54)72(34-7-5-6-16-61(74)69-32-12-37-89-48-21-26-56-53(39-48)52(31-33-68-56)64(76)70-43-62(75)71-36-11-15-46(71)42-67)59(65)29-17-44-13-10-14-45(63(44)90-47-19-22-49(23-20-47)92(80,81)82)18-30-60-66(3,4)55-41-51(94(86,87)88)25-28-58(55)73(60)35-8-9-38-91(77,78)79/h17-31,33,39-41,46H,5-16,32,34-38,43H2,1-4H3,(H5-,69,70,74,76,77,78,79,80,81,82,83,84,85,86,87,88)/t46-/m0/s1 |
| InChIKey | JPMCOMGUYMABHG-DXQCBLCSSA-N |
| SMILES | O=S(C1=CC2=C(C=C1)[N+](CCCCCC(NCCCOC3=CC=C4N=CC=C(C4=C3)C(NCC(N5[C@@H](CCC5)C#N)=O)=O)=O)=C(C2(C)C)/C=C/C6=C(/C(CCC6)=C/C=C7N(C8=C(C/7(C)C)C=C(C=C8)S(=O)(O)=O)CCCCS(=O)(O)=O)OC9=CC=C(C=C9)S(=O)(O)=O)([O-])=O |
| Reference | 1: Slania SL, Das D, Lisok A, Du Y, Jiang Z, Mease RC, Rowe SP, Nimmagadda S, Yang X, Pomper MG. Imaging of Fibroblast Activation Protein in Cancer Xenografts Using Novel (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine-Based Small Molecules. J Med Chem. 2021 Mar 17. doi: 10.1021/acs.jmedchem.0c02171. Epub ahead of print. PMID: 33730493. |
