For research use only. Not for therapeutic Use.
QM295 is an endoplasmic reticulum oxidation 1 (ERO1) inhibitor with selectively reversible thiol reactivity. QM295 can be used for the research of endoplasmic reticulum stress[1].
QM295 (25 μM, 50 μM) inhibits the development of AUR fluorescence in a kinetic assay with an IC50 value of 1.9 μM[1].
QM295 (50 μM, 30 min) has the accumulation of an ERO1α form with lower mobility in vivo[1].
| Catalog Number | I042301 |
| CAS Number | 1241046-32-1 |
| Synonyms | (4Z)-4-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-phenyl-1,2-oxazol-5-one |
| Molecular Formula | C17H13NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H13NO4/c1-21-15-10-11(7-8-14(15)19)9-13-16(18-22-17(13)20)12-5-3-2-4-6-12/h2-10,19H,1H3/b13-9- |
| InChIKey | LRCZCFNUNZQGGK-LCYFTJDESA-N |
| SMILES | COC1=C(C=CC(=C1)C=C2C(=NOC2=O)C3=CC=CC=C3)O |
| Reference | [1]. Jaime D Blais, et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003. |
