For research use only. Not for therapeutic Use.
QM31(Cat No.:I017407), also known as SVT016426, is a cytoprotective agent that acts as a selective inhibitor of Apaf-1. It effectively inhibits the formation of the apoptosome, which is the caspase activation complex composed of Apaf-1, cytochrome c, dATP, and caspase-9. With an IC50 of 7.9 μM, QM31 hinders the assembly of the apoptosome, thereby preventing caspase activation. Additionally, QM31 exhibits mitochondria protective properties and interferes with the intra-S-phase DNA damage checkpoint. In HeLa S100 cells, SVT016426 inhibits Apaf1-induced activation of caspase activity with an IC50 of 5 μM. These findings suggest the potential of QM31 as a therapeutic agent for modulating apoptotic pathways and protecting against cellular damage.
| Catalog Number | I017407 |
| CAS Number | 937735-00-7 |
| Molecular Formula | C₃₉H₃₈Cl₄N₄O₄ |
| Purity | ≥95% |
| Target | Caspase |
| IUPAC Name | N-(2-amino-2-oxoethyl)-N,1-bis[2-(2,4-dichlorophenyl)ethyl]-4-(3,3-diphenylpropyl)-3,7-dioxo-1,4-diazepane-5-carboxamide |
| InChI | InChI=1S/C39H38Cl4N4O4/c40-30-13-11-28(33(42)21-30)15-18-45-25-38(50)47(20-17-32(26-7-3-1-4-8-26)27-9-5-2-6-10-27)35(23-37(45)49)39(51)46(24-36(44)48)19-16-29-12-14-31(41)22-34(29)43/h1-14,21-22,32,35H,15-20,23-25H2,(H2,44,48) |
| InChIKey | YSUHYGYGQFSKDT-UHFFFAOYSA-N |
| SMILES | C1C(N(C(=O)CN(C1=O)CCC2=C(C=C(C=C2)Cl)Cl)CCC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)N(CCC5=C(C=C(C=C5)Cl)Cl)CC(=O)N |
| Reference | [1]. Mondragón L, et al. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. Apoptosis. 2009 Feb;14(2):182-90.<br>[2]. Orzáez M, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014 Oct 20;9(10):e110979.<br>[3]. Gortat A, et al. Apaf1 inhibition promotes cell recovery from apoptosis. Protein Cell. 2015 Nov;6(11):833-43. |
