For research use only. Not for therapeutic Use.
QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1].
QM385 effectively inhibits the proliferation of human CD4+ T cells at low doses[1].
| Catalog Number | I019062 |
| CAS Number | 2093421-02-2 |
| Synonyms | 2-[5-methyl-4-[4-(2,2,2-trifluoroethyl)piperazine-1-carbonyl]pyrazol-1-yl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one |
| Molecular Formula | C17H18F3N7O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H18F3N7O2/c1-11-12(15(29)25-7-5-24(6-8-25)10-17(18,19)20)9-21-27(11)16-22-14(28)13-3-2-4-26(13)23-16/h2-4,9H,5-8,10H2,1H3,(H,22,23,28) |
| InChIKey | GPMQVMCLRRPIIE-UHFFFAOYSA-N |
| SMILES | CC1=C(C=NN1C2=NN3C=CC=C3C(=O)N2)C(=O)N4CCN(CC4)CC(F)(F)F |
| Reference | [1]. Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563(7732):564-568. |
