For research use only. Not for therapeutic Use.
QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer[1].
QN523 (72 h) has cytotoxicity with IC50 values ranging from 0.1 to 5.7 μM across 12 cell lines[1].
QN523 (0.1 and 0.5 μM; 24 and 48 h; MIA PaCa-2 cells) arrests cell cycle at S phase and delays for pancreatic cancer cells to enter the G2-M phase. QN523 induces apoptosis and autophagy of MIA PaCa-2 Cells[1].
QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts[1].
| Catalog Number | I042638 |
| CAS Number | 878581-60-3 |
| Synonyms | N-quinolin-8-ylpyrazine-2-carboxamide |
| Molecular Formula | C14H10N4O |
| Purity | ≥95% |
| InChI | InChI=1S/C14H10N4O/c19-14(12-9-15-7-8-16-12)18-11-5-1-3-10-4-2-6-17-13(10)11/h1-9H,(H,18,19) |
| InChIKey | CYTYVKQBOOTXRP-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C(=C1)NC(=O)C3=NC=CN=C3)N=CC=C2 |
| Reference | [1]. Kuang Y, et, al. Induction of Genes Implicated in Stress Response and Autophagy by a Novel Quinolin-8-yl-nicotinamide QN523 in Pancreatic Cancer. J Med Chem. 2022 Apr 28;65(8):6133-6156. |
