For research use only. Not for therapeutic Use.
QND7 is a α7-nicotinic acetylcholine receptor antagonist (Ka value of 6.7 μM). QND7 suppresses non-small cell lung cancer cell proliferation and migration via inhibition of Akt/mTOR signaling.
KEYWORDS: QND7 | supplier | nAChR antagonist | QND 7 | QND-7 | CAS [1779540-13-4] | Acetylcholine | nAChR | Antagonist | Ion Channels | Non-small cell lung cancer | NSCLC
| Catalog Number | I047647 |
| CAS Number | 1779540-13-4 |
| Molecular Formula | C21H22N4 |
| Purity | ≥95% |
| IUPAC Name | 3-[4-(4-phenylphenyl)triazol-1-yl]-1-azabicyclo[2.2.2]octane |
| InChI | InChI=1S/C21H22N4/c1-2-4-16(5-3-1)17-6-8-18(9-7-17)20-14-25(23-22-20)21-15-24-12-10-19(21)11-13-24/h1-9,14,19,21H,10-13,15H2 |
| SMILES | C1CN2CCC1C(C2)N3C=C(N=N3)C4=CC=C(C=C4)C5=CC=CC=C5 |
| Reference | W Witayateeraporn et al. α7-Nicotinic acetylcholine receptor antagonist QND7 suppresses non-small cell lung cancer cell proliferation and migration via inhibition of Akt/mTOR signaling. Biochem Biophys Res Commun. 2020 Jan 22;521(4):977-983. K Arunrungvichian et al. Selectivity optimization of substituted 1,2,3-triazoles as α7 nicotinic acetylcholine receptor agonists. ACS Chem Neurosci. 2015;6(8):1317-1330. |
