For research use only. Not for therapeutic Use.
QO-40 is a pyrazolo[1,5-a]pyrimidine-7(4H)-one (PPO) derivative and an activator of the voltage-gated M-type potassium channel KCNQ encoded by the KCNQ2/3 gene (EC50: 1.25 μM)[1][2].
QO-40 (100 μM) increases KCNQ2/3 currents in CHO cells[1].
| Catalog Number | I035316 |
| CAS Number | 1259536-70-3 |
| Synonyms | 5-(chloromethyl)-3-naphthalen-1-yl-2-(trifluoromethyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one |
| Molecular Formula | C18H11ClF3N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C18H11ClF3N3O/c19-9-11-8-14(26)25-17(23-11)15(16(24-25)18(20,21)22)13-7-3-5-10-4-1-2-6-12(10)13/h1-8,24H,9H2 |
| InChIKey | PAIKWVVGBGIKJH-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C=CC=C2C3=C(NN4C3=NC(=CC4=O)CCl)C(F)(F)F |
| Reference | [1]. Jia C, et al. Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives. Pharmacology. 2011;87(5-6):297-310. |
