For research use only. Not for therapeutic Use.
QR-0217 is a potent Aβ1-40 aggregation inhibitor with an IC50 value of 7.5 µM. QR-0217 inhibits α-synuclein aggregation. QR-0217 reduces memory impairments caused by Aβ neurotoxicity[1].
QR-0217 (20, 100 µM; 96 h) inhibits α-synuclein (4 μM) aggregation[1].
QR-0217 (50 µM) significantly rescues impairment of LTP in the APP/PS1 transgenic mice hippocampal slices[1].
| Catalog Number | I041162 |
| CAS Number | 1027786-12-4 |
| Synonyms | 3-(6-hydroxynaphthalen-2-yl)-1H-indole-5-carboxylic acid |
| Molecular Formula | C19H13NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H13NO3/c21-15-5-3-11-7-13(2-1-12(11)8-15)17-10-20-18-6-4-14(19(22)23)9-16(17)18/h1-10,20-21H,(H,22,23) |
| InChIKey | OPTWFLWYDUFHPL-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=CC(=C2)O)C=C1C3=CNC4=C3C=C(C=C4)C(=O)O |
| Reference | [1]. Michael D. Carter, et al. Compounds and methods for treating protein folding disorders. US8362066B2. |
