For research use only. Not for therapeutic Use.
Quetiapine hemifumarate（Cat No.:I008939）is the salt form of quetiapine, an atypical antipsychotic used to treat mental health conditions such as schizophrenia, bipolar disorder, and major depressive disorder. It works by modulating neurotransmitter activity in the brain, particularly dopamine and serotonin receptors, to help alleviate symptoms like hallucinations, mood swings, and depression. Quetiapine hemifumarate is often prescribed for both short-term and long-term management of these conditions and may also be used off-label for anxiety or insomnia. While generally effective, it can cause side effects like sedation, weight gain, and metabolic changes.
| Catalog Number | I008939 |
| CAS Number | 111974-72-2 (hemifumarate) |
| Synonyms | ICI 204,636; IC-204,636; ICI204,636; ICI-204636; ICI 204636; ICI204636; Quetiapine Fumarate; Quetiapine hemifumarate; Seroquel XR.;2-(2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethan-1-ol hemifumarate |
| Molecular Formula | C46H54N6O8S2 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol;(E)-but-2-enedioic acid |
| InChI | InChI=1S/2C21H25N3O2S.C4H4O4/c2*25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h2*1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+ |
| InChIKey | ZTHJULTYCAQOIJ-WXXKFALUSA-N |
| SMILES | C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C(=C/C(=O)O)\C(=O)O |
| Reference | </br>1:Aseptic gingivitis related to quetiapine hemifumarate. Gahr M, Kölle MA, Freudenmann RW, Schönfeldt-Lecuona C.Pharmacopsychiatry. 2013 Jan;46(1):39-40. doi: 10.1055/s-0032-1321906. Epub 2012 Aug 22. PMID: 22915485 </br>2:Acidity of several polyprotic acids, amiodarone and quetiapine hemifumarate in pure methanol. Garrido G, de Nogales V, Ràfols C, Bosch E.Talanta. 2007 Aug 15;73(1):115-20. doi: 10.1016/j.talanta.2007.03.010. Epub 2007 Mar 14. PMID: 19071857 |
