For research use only. Not for therapeutic Use.
Quiflapon (Cat No.:I001412) is a highly selective and specific inhibitor of 5-lipoxygenase-activating protein (FLAP) with an IC50 value of 1.6nM. It is also a potent inhibitor of leukotriene biosynthesis, with IC50 values of 3.1nM and 6.1nM in intact human and induced rat polymorphonuclear leukocyte PMNLs, respectively. Quiflapon can induce apoptosis, a process of programmed cell death.
| Catalog Number | I001412 |
| CAS Number | 136668-42-3 |
| Synonyms | 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid |
| Molecular Formula | C34H35ClN2O3S |
| Purity | 98% |
| Target | FLAP; Apoptosis |
| Solubility | 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Related CAS | 147030-01-1 (sodium) |
| IC50 | 1.6 nM |
| IUPAC Name | 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid |
| InChI | InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39) |
| InChIKey | NZOONKHCNQFYCI-UHFFFAOYSA-N |
| SMILES | CC(C)(C)SC1=C(N(C2=C1C=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)CC5=CC=C(C=C5)Cl)CC(C)(C)C(=O)O |
