For research use only. Not for therapeutic Use.
Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer[1][2].
Quinagolide hydrochloride (100 nM; 48 h) reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression in ectopic lines[2].
Quinagolide hydrochloride (100 nM; 48 h) inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs)[2].
Quinagolide hydrochloride (100 nM; 24 h) significantly reduces the endothelial differentiation of E-MSCs[2].
Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo[1].
| Catalog Number | I008944 |
| CAS Number | 94424-50-7 |
| Synonyms | (3S,4aS,10aR)-3-(diethylsulfamoylamino)-6-hydroxy-1-propyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline;hydrochloride |
| Molecular Formula | C20H34ClN3O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H33N3O3S.ClH/c1-4-10-22-14-17(21-27(25,26)23(5-2)6-3)11-16-12-18-15(13-19(16)22)8-7-9-20(18)24;/h7-9,16-17,19,21,24H,4-6,10-14H2,1-3H3;1H/t16-,17+,19-;/m1./s1 |
| InChIKey | DVLKVIJLALMCBQ-MSSRUXLCSA-N |
| SMILES | CCCN1CC(CC2C1CC3=C(C2)C(=CC=C3)O)NS(=O)(=O)N(CC)CC.Cl |
| Reference | [1]. Trouillas J, et al. Inhibitory effects of the dopamine agonists quinagolide (CV 205-502) and bromocriptine on prolactin secretion and growth of SMtTW pituitary tumors in the rat. Endocrinology. 1994 Jan;134(1):401-10. [2]. Iampietro C, et al. Quinagolide Treatment Reduces Invasive and Angiogenic Properties of Endometrial Mesenchymal Stromal Cells. Int J Mol Sci. 2022 Feb 4;23(3):1775. |
