Quinapril-d5 Hydrochloride

• CAT Number: R005537
• CAS Number: 1356020-03-5
• Molecular Formula: C25H31ClN2O5
• Molecular Weight: 480.013
• Purity: ≥95%
• Synonyms: CI-906-d5, PD-109452-2-d5, Accupril-d5, Accuprin-d5, Accupro-d5; Korec-d5; Korectic-d5
• Storage: -20°C
• IUPAC Name: (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-(2,3,4,5,6-pentadeuteriophenyl)butan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;hydrochloride
• InChI: InChI=1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1/i4D,5D,6D,9D,10D
• InChIKey: IBBLRJGOOANPTQ-GOMJJGCLSA-N
• SMILES: [2H]C1=C(C(=C(C(=C1[2H])[2H])CC[C@H](C(=O)OCC)NC(C)C(=O)N2CC3=CC=CC=C3C[C@H]2C(=O)O)[2H])[2H].Cl

Quinapril-d5 Hydrochloride is a deuterated form of quinapril, an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and heart failure. The five deuterium atoms replace hydrogen atoms in the molecule, providing a stable isotopic label for enhanced precision in pharmacokinetic and metabolic studies. This labeled compound allows for accurate tracking of the drug’s absorption, distribution, metabolism, and excretion in biological systems. Its applications are significant in pharmaceutical research for optimizing drug formulations, studying drug interactions, and improving therapeutic strategies for managing cardiovascular conditions.