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82586-55-8-Quinapril Hydrochloride Quinapril Hydrochloride

Quinapril Hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: A000224
  • CAS Number: 82586-55-8
  • Molecular Formula: C25H31ClN2O5
  • Molecular Weight: 475
  • Purity: ≥95%
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Related Small Molecules: Levamisole hydrochloride     Flunixin Meglumin     Cefotaxime Sodium    

Quinapril Hydrochloride is an angiotensin-converting enzyme inhibitor. Quinapril is a prodrug that is converted to its active metabolite, quinaprilat. Quinapril’s target catalyses the formation of angiotensin II from its precursor, angiotensin I. Angiotensin II is a potent vasoconstrictor and thus preventing its formation causes vasodilation and an increased capillary blood volume.


Catalog Number A000224
CAS Number 82586-55-8
Synonyms

Accupril; 82586-55-8; Accuprin; Acequin; Quinazil

Molecular Formula C25H31ClN2O5
Purity ≥95%
Target Angiotensin-converting Enzyme (ACE)
Storage -20°C
InChIKey IBBLRJGOOANPTQ-JKVLGAQCSA-N
Reference

1: Stolarczyk M, Maślanka A, Apola A, Krzek J. Determination of losartan
potassium, quinapril hydrochloride and hydrochlorothiazide in pharmaceutical
preparations using derivative spectrophotometry and chromatographic-densitometric
method. Acta Pol Pharm. 2013 Nov-Dec;70(6):967-76. PubMed PMID: 24383320.
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2: Hailu SA, Bogner RH. Complex effects of drug/silicate ratio, solid-state
equivalent pH, and moisture on chemical stability of amorphous quinapril
hydrochloride coground with silicates. J Pharm Sci. 2011 Apr;100(4):1503-15. doi:
10.1002/jps.22387. Epub 2010 Nov 24. PubMed PMID: 24081473.

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3: Stanisz B, Paszun S, Strzyzycka N, Ptaszyński E. Influence of humidity and
hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or
magnesium stearate on the degradation kinetics of quinapril hydrochloride in
solid phase. Acta Pol Pharm. 2010 Jan-Feb;67(1):99-102. PubMed PMID: 20210086.
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4: Hailu SA, Bogner RH. Solid-state surface acidity and pH-stability profiles of
amorphous quinapril hydrochloride and silicate formulations. J Pharm Sci. 2010
Jun;99(6):2786-99. doi: 10.1002/jps.22051. PubMed PMID: 20091829.
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5: Hailu SA, Bogner RH. Effect of the pH grade of silicates on chemical stability
of coground amorphous quinapril hydrochloride and its stabilization using
pH-modifiers. J Pharm Sci. 2009 Sep;98(9):3358-72. doi: 10.1002/jps.21767. PubMed
PMID: 19363809.

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6: Rojanasthien N, Nasangiam N, Kumsorn B, Roongapinun S, Jengjareon A.
Pharmacokinetics and bioequivalence study of the two 20-mg quinapril
hydrochloride tablet formulations in healthy Thai male volunteers. J Med Assoc
Thai. 2008 May;91(5):739-46. PubMed PMID: 18672641.
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7: Bhavar GB, Chatpalliwar VA, Patil DD, Surana SJ. Validated HPTLC Method for
Simultaneous Determination of Quinapril Hydrochloride and Hydrochlorothiazide in
a Tablet Dosage Form. Indian J Pharm Sci. 2008 Jul-Aug;70(4):529-31. doi:
10.4103/0250-474X.44612. PubMed PMID: 20046789; PubMed Central PMCID: PMC2792558.
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8: Stanisz B. The influence of pharmaceutical excipients on quinapril
hydrochloride stability. Acta Pol Pharm. 2005 May-Jun;62(3):189-93. PubMed PMID:
16193811.
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9: Stanisz B. The stability of quinapril hydrochloride–a mixture of amorphous
and crystalline forms (QHCl-AC)–in solid phase. Acta Pol Pharm. 2003
Nov-Dec;60(6):443-9. PubMed PMID: 15080591.
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10: Stanisz B. Kinetics of degradation of quinapril hydrochloride in tablets.
Pharmazie. 2003 Apr;58(4):249-51. PubMed PMID: 12749406.

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