For research use only. Not for therapeutic Use.
Quinidine is a dextrorotatory stereoisomer of quinine with antimalarial and antiarrhythmic properties.
| Catalog Number | R007506 |
| CAS Number | 56-54-2 |
| Synonyms | (9S)-6’-Methoxycinchonan-9-ol; (+)-Quinidine; (8R,9S)-Quinidine; Chinidin; Cin-quin; Conchinin; Conchinine; Conquinine; Kinidin; Pitayin; Pitayine; Quindine; β-Quinidine; β-Quinine; |
| Molecular Formula | C20H24N2O2 |
| Purity | ≥95% |
| Target | Other Channel Modulators |
| Solubility | >12mg/mL in DMSO |
| Storage | Store at -20C |
| Reference | </br>1:Quinidine for Brugada syndrome: Panacea or poison? Hai JJ, Wong CK, Chan PH, Tse HF, Yung TC, Siu CW.HeartRhythm Case Rep. 2016 Aug 16;2(6):486-490. doi: 10.1016/j.hrcr.2016.07.002. eCollection 2016 Nov. No abstract available. PMID: 28491743 Free PMC Article</br>2:Dextromethorphan/quinidine pharmacotherapy in patients with treatment resistant depression: A proof of concept clinical trial. Murrough JW, Wade E, Sayed S, Ahle G, Kiraly DD, Welch A, Collins KA, Soleimani L, Iosifescu DV, Charney DS.J Affect Disord. 2017 Apr 29;218:277-283. doi: 10.1016/j.jad.2017.04.072. [Epub ahead of print] PMID: 28478356 </br>3:Assessing the clinical efficacy of quinidine in Brugada syndrome: /Mission: Impossible/? Belhassen B.Heart Rhythm. 2017 Apr 26. pii: S1547-5271(17)30501-5. doi: 10.1016/j.hrthm.2017.04.034. [Epub ahead of print] No abstract available. PMID: 28455270 </br>4:Liquid and subcritical fluid chromatographic enantioseparation of N<sup>α</sup> -Fmoc proteinogenic amino acids on Quinidine-based zwitterionic and anion-exchanger type chiral stationary phases. A comparative study. Lajkó G, Grecsó N, Tóth G, Fülöp F, Lindner W, Ilisz I, Péter A.Chirality. 2017 Apr 19. doi: 10.1002/chir.22700. [Epub ahead of print] PMID: 28422383 </br>5:Antitachycardia Pacing Effectiveness for Monomorphic Ventricular Tachycardia in Brugada Syndrome After Quinidine Administration. Dallaglio PD, Anguera I, García-Alberola A, Sabaté X, Cequier Á, Brugada J.Rev Esp Cardiol (Engl Ed). 2017 Mar 31. pii: S1885-5857(17)30121-4. doi: 10.1016/j.rec.2017.03.002. [Epub ahead of print] English, Spanish. No abstract available. PMID: 28372913 </br>6:Trial of dextromethorphan/quinidine to treat levodopa-induced dyskinesia in Parkinson/’s disease. Fox SH, Metman LV, Nutt JG, Brodsky M, Factor SA, Lang AE, Pope LE, Knowles N, Siffert J.Mov Disord. 2017 Mar 30. doi: 10.1002/mds.26976. [Epub ahead of print] PMID: 28370447 </br>7:Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP<sub>2</sub>-interference. Koepple C, Scherer D, Seyler C, Scholz E, Thomas D, Katus HA, Zitron E.J Pharmacol Exp Ther. 2017 May;361(2):209-218. doi: 10.1124/jpet.116.238287. Epub 2017 Feb 10. PMID: 28188270 </br>8:Intramolecular Hydrogen Bonds in Conformers of Quinine and Quinidine: An HF, MP2 and DFT Study. Bilonda MK, Mammino L.Molecules. 2017 Feb 7;22(2). pii: E245. doi: 10.3390/molecules22020245. PMID: 28178218 Free Article</br>9:Consequences of daily corticosteroid dosing with or without pre-treatment with quinidine on the in vivo cytochrome P450 2D (CYP2D) enzyme in rats: effect on O-demethylation activity of dextromethorphan and expression levels of CYP2D1 mRNA. Giri P, Delvadia P, Gupta L, Patel N, Trivedi P, Lad K, Patel HM, Srinivas NR.Xenobiotica. 2017 Jan 19:1-10. doi: 10.1080/00498254.2016.1275064. [Epub ahead of print] PMID: 28010169 </br>10:Use of Compounded Dextromethorphan-Quinidine Suspension for Pseudobulbar Affect in Hospice Patients. Wahler RG Jr, Reiman AT, Schrader JV.J Palliat Med. 2017 Mar;20(3):294-297. doi: 10.1089/jpm.2016.0277. Epub 2016 Dec 20. PMID: 27997281 |
