Quinidine

• CAT Number: R007506
• CAS Number: 56-54-2
• Molecular Formula: C20H24N2O2
• Molecular Weight: 324.42
• Purity: ≥95%
• Synonyms: (9S)-6’-Methoxycinchonan-9-ol; (+)-Quinidine; (8R,9S)-Quinidine; Chinidin; Cin-quin; Conchinin; Conchinine; Conquinine; Kinidin; Pitayin; Pitayine; Quindine; β-Quinidine; β-Quinine
• Target: Metabolic Enzyme/Protease
• Solubility: >12mg/mL in DMSO
• Storage: Store at -20℃
• IUPAC Name: (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
• InChI: 1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
• InChIKey: LOUPRKONTZGTKE-LHHVKLHASA-N
• SMILES: COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O

Quinidine is an alkaloid derived from the bark of the Cinchona tree, widely used in research for its antiarrhythmic and antimalarial properties. As a Class Ia antiarrhythmic agent, it inhibits sodium and potassium channels, prolonging the cardiac action potential and refractory period, making it effective for studying arrhythmias. Quinidine also exhibits activity against Plasmodium falciparum, contributing to antimalarial research. Additionally, it is a P-glycoprotein inhibitor, valuable in pharmacokinetic studies for investigating drug-drug interactions and multidrug resistance mechanisms in cancer therapy.