Quinomycin A

• CAT Number: M019914
• CAS Number: 512-64-1
• Molecular Formula: C51H64N12O12S2
• Molecular Weight: 1101.30
• Purity: ≥95%
• Synonyms: echinomycina;nsc526417;ECHINOMYCIN;QUINOMYCIN A;N-[(1R,4S,8R,11S,14R,17S,21R,24S)-3,11,13,16,24,26-hexamethyl-27-methylsulfanyl-2,5,9,12,15,18,22,25-octaoxo-4,17-di(propan-2-yl)-8-(quinoxaline-2-carbonylamino)-6,19-dioxa-28-thia-3,10,13,16,23,26-hexa
• Storage: -20°C
• IUPAC Name: N-[2,4,12,15,17,25-hexamethyl-27-methylsulfanyl-3,6,10,13,16,19,23,26-octaoxo-11,24-di(propan-2-yl)-20-(quinoxaline-2-carbonylamino)-9,22-dioxa-28-thia-2,5,12,15,18,25-hexazabicyclo[12.12.3]nonacosan-7-yl]quinoxaline-2-carboxamide
• InChI: InChI=1S/C51H64N12O12S2/c1-25(2)38-49(72)74-22-36(59-42(65)34-21-53-30-17-13-15-19-32(30)57-34)44(67)55-28(6)46(69)63(10)40-48(71)62(9)39(26(3)4)50(73)75-23-35(58-41(64)33-20-52-29-16-12-14-18-31(29)56-33)43(66)54-27(5)45(68)60(7)37(47(70)61(38)8)24-77-51(40)76-11/h12-21,25-28,35-40,51H,22-24H2,1-11H3,(H,54,66)(H,55,67)(H,58,64)(H,59,65)
• InChIKey: AUJXLBOHYWTPFV-UHFFFAOYSA-N
• SMILES: CC1C(=O)N(C2CSC(C(C(=O)N(C(C(=O)OCC(C(=O)N1)NC(=O)C3=NC4=CC=CC=C4N=C3)C(C)C)C)N(C(=O)C(NC(=O)C(COC(=O)C(N(C2=O)C)C(C)C)NC(=O)C5=NC6=CC=CC=C6N=C5)C)C)SC)C

Quinomycin A（Cat No.:M019914）is a cyclic peptide antibiotic belonging to the quinoxaline family, known for its potent anti-tumor and antimicrobial activities. Derived from Streptomyces species, Quinomycin A intercalates with DNA, preventing DNA and RNA synthesis, which makes it effective in inhibiting the growth of cancer cells and various pathogens. Its selective cytotoxicity against certain tumor cells has drawn attention in cancer research, particularly in targeting resistant cancers. Due to its high bioactivity, Quinomycin A is extensively studied as a lead compound for developing novel anticancer and antibiotic therapies.

Reference

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