For research use only. Not for therapeutic Use.
Quinupristin-dalfopristin (Cat.No:M118102) is a combination antibiotic used to treat infections caused by multidrug-resistant bacteria, particularly strains of Gram-positive cocci like methicillin-resistant Staphylococcus aureus (MRSA). It works by inhibiting bacterial protein synthesis. This drug is primarily administered intravenously and is employed when other antibiotics have proven ineffective.
| CAS Number | 126602-89-9 |
| Synonyms | Synercid; Quinupristin and dalfopristin; Quinupristin – dalfopristin mixt; Dalfopristin mixture with Quinupristin |
| Molecular Formula | C54H71N9O13S2 (for quinupristin mesylate); C35H54N4O12S2 (for dalfopristin mesylate) |
| Purity | ≥95% |
| Storage | Store at RT |
| IUPAC Name | N-[(3S,6S,12R,15S,16R,19S,22S,25R)-25-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]sulfanylmethyl]-3-[[4-(dimethylamino)phenyl]methyl]-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentazatricyclo[20.4.0.06,10]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide;(6R,7S,10R,11R,12E,17E,19E,21S)-6-[2-(diethylamino)ethylsulfonyl]-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetrone |
| InChI | InChI=1S/C53H67N9O10S.C34H50N4O9S/c1-6-37-50(68)61-23-11-14-38(61)51(69)59(5)40(26-32-16-18-36(19-17-32)58(3)4)52(70)62-28-35(30-73-43-29-60-24-20-33(43)21-25-60)42(64)27-39(62)47(65)57-45(34-12-8-7-9-13-34)53(71)72-31(2)44(48(66)55-37)56-49(67)46-41(63)15-10-22-54-46;1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h7-10,12-13,15-19,22,31,33,35,37-40,43-45,63H,6,11,14,20-21,23-30H2,1-5H3,(H,55,66)(H,56,67)(H,57,65);9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b;10-9+,12-11+,23-18+/t31-,35+,37-,38+,39+,40+,43-,44+,45+;24-,25-,28-,31-,32-/m11/s1 |
| InChIKey | PPKJUHVNTMYXOD-PZGPJMECSA-N |
| SMILES | CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)C3CC(=O)[C@H](CS[C@@H]4CN5CCC4CC5)CN3C(=O)[C@H](Cc6ccc(cc6)N(C)C)N(C)C(=O)[C@@H]7CCCN7C1=O)c8ccccc8.CCN(CC)CCS(=O)(=O)[C@@H]9CCN%10[C@H]9C(=O)O[C@H](C(C)C)[C@H](C)C=CC(=O)NCC=CC(=C[C@@H](O)CC(=O)Cc%11occ(n%11)C%10=O)C |
| Reference | 1.Quinupristin/dalfopristin (RP 59500): A new streptogramin antibiotic. Chant C. et al. Ann. Pharm. 1995, 29, 1022.<br /> |
