For research use only. Not for therapeutic Use.
Quizartinib Dihydrochloride (CAS 1132827-21-4) is a selective and potent inhibitor of FLT3 (Fms-like tyrosine kinase 3), a receptor tyrosine kinase often mutated in acute myeloid leukemia (AML). By specifically targeting FLT3-ITD (internal tandem duplication) mutations, Quizartinib impedes aberrant signaling pathways that contribute to leukemic cell proliferation. This makes it a promising therapeutic candidate for treating AML patients with FLT3 mutations.
| Catalog Number | I048004 |
| CAS Number | 1132827-21-4 |
| Synonyms | AC-220 dihydrochloride; vanflyta |
| Molecular Formula | C29H34Cl2N6O4S |
| Purity | 98% |
| Target | FLT3 |
| Target Protein | DHYPGRVMIOATAE-UHFFFAOYSA-N |
| Appearance | Solid |
| IUPAC Name | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea;dihydrochloride |
| InChI | InChI=1S/C29H32N6O4S.2ClH/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34;;/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36);2*1H |
| InChIKey | DHYPGRVMIOATAE-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3.Cl.Cl |
