QX 314 Bromide

• CAT Number: R024057
• CAS Number: 24003-58-5
• Molecular Formula: C16H27BrN2O
• Molecular Weight: 343.309
• Purity: ≥95%
• Synonyms: 2-[(2,6-Dimethylphenyl)amino]-N,N,N-triethyl-2-oxo-ethanaminium Bromide;?Triethyl[(2,6-xylylcarbamoyl)methyl]-ammonium Bromide; 2-[(2,6-Dimethylphenyl)amino]-N,N,N-triethyl-2-oxo-ethanaminium Bromide; N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammo
• Target: Sodium Channel
• Solubility: Soluble to 100 mM in sterile water
• Storage: Desiccate at RT
• IUPAC Name: [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium;bromide
• InChI: InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
• InChIKey: DLHMKHREUTXMCH-UHFFFAOYSA-N
• SMILES: CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-]

QX 314 Bromide(CAT: R024057) is a compound known for its role in inhibiting voltage-activated sodium channels. It is a quaternary derivative of lidocaine, rendering it membrane impermeable. Its action method involves its ability to block sodium channels, particularly in neurons. This property makes it valuable in electrophysiological experiments and studies of neural function. Additionally, QX 314 Bromide has been found to inhibit calcium currents in hippocampal CA1 pyramidal neurons, expanding its utility in neurobiology research.

Reference

1:Sci Rep. 2016 Dec 7;6:38582. doi: 10.1038/srep38582. Effects of Liposomes Charge on Extending Sciatic Nerve Blockade of N-ethyl Bromide of Lidocaine in Rats.Yin Q,Ke B,Chen X,Guan Y,Feng P,Chen G,Kang Y,Zhang W,Nie Y, PMID: 27924842 PMCID: PMC5141481 DOI: 10.1038/srep38582 Abstract: N-methyl bromide of lidocaine (QX-314) is a potential local anaesthetic with compromised penetration through cell membranes due to its obligated positive charge. Liposomes have been widely used for drug delivery with promising efficacy and safety. Therefore we investigated the local anaesthetic effects and tissue reactions of QX-314 in combination with anionic, cationic or neutral liposomes in rat sciatic nerve block model, and explored the effects of these liposomes on cellular entry of QX-314 in human embryonic kidney 293 cells. The results demonstrated that anionic liposomes substantially prolonged the duration of sensory (25.7 ± 8.3 h) and motor (41.4 ± 6.1 h) blocks of QX-314, while cationic and neutral ones had little effects. Tissue reactions from QX-314 with anionic liposomes were similar to those with commonly used local anaesthetic bupivacaine. Consistent with in vivo results, the anionic liposomes produced the greatest promotion of cellular entry of QX-314 in a time-dependent manner. In conclusion, ultra-long lasting nerve blocks were achieved by a mixture of QX-314 and anionic liposomes with a satisfactory safety profile, indicating a potential approach to improve postoperative pain management. The liposome-induced enhancement in cellular uptake of QX-314 may underlie the in vivo effects.