QX-314 chloride

For research use only. Not for therapeutic Use.

  • CAT Number: I011801
  • CAS Number: 5369-03-9
  • Molecular Formula: C16H27ClN2O
  • Molecular Weight: 298.85
  • Purity: ≥95%
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QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1].
QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro[2].?
QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[2].?
QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude[2].


Catalog Number I011801
CAS Number 5369-03-9
Synonyms

[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium;chloride

Molecular Formula C16H27ClN2O
Purity ≥95%
InChI InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
InChIKey LLPPOMUAOGMYQI-UHFFFAOYSA-N
SMILES CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Cl-]
Reference

[1]. Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114(6):1425-34.
 [Content Brief]

[2]. Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76(3):2120-4.
 [Content Brief]

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