QX77

• CAT Number: I020063
• CAS Number: 1798331-92-6
• Molecular Formula: C₁₆H₁₃ClN₂O₂
• Molecular Weight: 300.74
• Purity: ≥95%
• Target: Autophagy
• Storage: Store at -20°C
• IUPAC Name: N-[4-(7-chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide
• InChI: InChI=1S/C16H13ClN2O2/c1-10(20)18-13-5-2-11(3-6-13)15-9-21-16-8-12(17)4-7-14(16)19-15/h2-8H,9H2,1H3,(H,18,20)
• InChIKey: PYCTUCLCTVWILY-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2

QX77（Cat No.:I020063）, a novel chaperone-mediated autophagy (CMA) activator, has been found to induce the upregulation of Rab11 and LAMP2A expression. This upregulation suggests that QX77 enhances CMA by promoting the expression of key proteins involved in CMA pathway regulation and cargo delivery. These findings highlight the potential of QX77 as a promising therapeutic agent for modulating CMA and promoting cellular clearance mechanisms.