(R)​-​Darifenacin

• CAT Number: R045174
• CAS Number: 133099-05-5
• Molecular Formula: C28H30N2O2
• Molecular Weight: 426.56
• Purity: ≥95%
• Synonyms: (R)​-1-​[2-​(2,​3-​Dihydro-​5-​benzofuranyl)​ethyl]​-​α,​α-​diphenyl-​3-​pyrrolidineacetamide​; (R)​-​(+)​-​3-​(1-​Carbamoyl-​1,​1-​diphenylmethyl)​-​1-​[2-(2,3-dihydrobenzofuran-​5-​yl)ethyl]pyrrolidine; ent-​Darifenacin
• Storage: -20 °C
• IUPAC Name: 2-[(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide
• InChI: InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m0/s1
• InChIKey: HXGBXQDTNZMWGS-VWLOTQADSA-N
• SMILES: C1CN(CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N)CCC4=CC5=C(C=C4)OCC5

(R)-Darifenacin(CAT: R045174) is the active enantiomer of darifenacin, a muscarinic receptor antagonist used to treat overactive bladder with symptoms of urinary incontinence, urgency, and frequency. It selectively targets the M3 muscarinic receptors, which are primarily responsible for bladder muscle contractions. By inhibiting these receptors, (R)-Darifenacin helps to relax the bladder muscles, reducing urinary urgency and improving bladder control. Its high selectivity for M3 receptors minimizes side effects related to other muscarinic receptors, making it a valuable treatment option in managing urinary disorders.