R-1479

• CAT Number: I003673
• CAS Number: 478182-28-4
• Molecular Formula: C9H12N6O5
• Molecular Weight: 284.23
• Purity: ≥95%
• Synonyms: 4-amino-1-[(2R,3R,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• Target: Cell Cycle/DNA Damage
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 1.28 uM (HCV replicon assay)
• InChI: InChI=1S/C9H12N6O5/c10-4-1-2-15(8(19)12-4)7-5(17)6(18)9(3-16,20-7)13-14-11/h1-2,5-7,16-18H,3H2,(H2,10,12,19)/t5-,6+,7-,9-/m1/s1
• InChIKey: ODLGMSQBFONGNG-JVZYCSMKSA-N
• SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@](O2)(CO)N=[N+]=[N-])O)O

R-1479（Cat No.:I003673）is a high-purity nucleoside analog and potent inhibitor of hepatitis C virus (HCV) RNA polymerase, essential for antiviral research. It selectively targets the NS5B polymerase, disrupting viral RNA synthesis and replication. Widely used in studies of HCV pathogenesis and drug development, R-1479 provides valuable insights into nucleoside-based therapeutic strategies. Its robust activity and metabolic stability make it an ideal tool for preclinical evaluations and the design of innovative antiviral treatments. R-1479 is critical for advancing research in HCV and RNA virus therapeutics.

Reference

[1]. Smith DB, et al. Design, synthesis, and antiviral properties of 4/’-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6.
[2]. Klumpp K, et al. The novel nucleoside analog R1479 (4/’-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. J Biol Chem. 2006 Feb 17;281(7):3793-9.