R-268712

• CAT Number: I005290
• CAS Number: 879487-87-3
• Molecular Formula: C20H18FN5O
• Molecular Weight: 363.39
• Purity: ≥95%
• Target: ALK5
• Solubility: 10 mM in DMSO
• Storage: Desiccate at +4C
• IC50: 2.5 nM [1]

R-268712 (Cat.No:I005290) is a potent and selective inhibitor of ALK5 (Activin receptor-like kinase 5), with an impressive IC50 value of 2.5 nM. ALK5 plays a crucial role in the TGF-β signaling pathway, regulating cell proliferation, differentiation, and development. R-268712 shows promise in research for potential therapeutic applications in cancer, fibrosis, and other diseases.

Reference

[1]. Terashima H, et al. R-268712, an orally active transforming growth factor-β type I receptor inhibitor, prevents glomerular sclerosis in a Thy1 nephritis model. Eur J Pharmacol. 2014 Jul 5;734:60-6.