For research use only. Not for therapeutic Use.
Optically pure (R)-enantiomer of 6-hydroxybuspirone (Axon 1996), a major active metabolite of Buspirone (Axon 1995); 5-HT1A partial agonist. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer; while (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the (R)-enantiomer
| Catalog Number | I047587 |
| CAS Number | 2108486-86-6 |
| Molecular Formula | C21H31N5O3.HCl |
| Purity | ≥95% |
| IUPAC Name | (10R)-10-hydroxy-8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride |
| InChI | InChI=1S/C21H31N5O3.ClH/c27-17-16-21(6-1-2-7-21)18(28)19(29)26(17)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9,18,28H,1-4,6-7,10-16H2;1H/t18-;/m0./s1 |
| SMILES | C1CCC2(C1)CC(=O)N(C(=O)[C@@H]2O)CCCCN3CCN(CC3)C4=NC=CC=N4.Cl |
| Reference | H Wong et al. 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats. Drug Metab. Dispos. 2007, 35(8), 1387-1392.
RC Dockens et al. Pharmacokinetics of 6-hydroxybuspirone and its enantiomers administered individually or following buspirone administration in humans. Biopharm. Drug Dispos. 2007, 28(7), 393-402.
SJ Nicholson et al. Development of oral extended release formulations of 6-hydroxybuspirone. Biopharm. Drug Dispos. 2012, 33(9), 522-535. |
