For research use only. Not for therapeutic Use.
(R)-<wbr></wbr>AM1241 avidly binds the peripheral cannabinoid receptor (CB<sub>2</sub>) (K<sub>i</sub> = 15 nM) with over 100-<wbr></wbr>fold selectivity over central cannabinoid receptor (CB<sub>1</sub>). Like the racemate AM1241 (Item No. <span class=/itemid/>10010118</span>), (R)-<wbr></wbr>AM1241 is an agonist of human CB<sub>2</sub>, but an inverse agonist of rat and mouse CB<sub>2</sub>. In rats, (R)-<wbr></wbr>AM1241 produces antinociception to thermal, but not mechanical, pain. The pain-<wbr></wbr>reducing effect of (R)-<wbr></wbr>AM1241 is blocked by the CB<sub>2</sub>-<wbr></wbr>specific inhibitor SR 144528, but not by either the CB<sub>1</sub>-<wbr></wbr>selective inhibitor rimonabant or the opioid receptor blocker naloxone.
| Catalog Number | R046248 |
| CAS Number | 444912-51-0 |
| Synonyms | (+)-AM1241 |
| Molecular Formula | C22H22IN3O3 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3/t16-/m1/s1 |
| InChIKey | ZUHIXXCLLBMBDW-MRXNPFEDSA-N |
| SMILES | CN1CCCCC1CN2C=C(C3=CC=CC=C32)C(=O)C4=C(C=CC(=C4)[N+](=O)[O-])I |
| Reference | 1.Bingham, B.,Jones, P.G.,Uveges, A.J., et al. Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers. British Journal of Pharmacology 151, 1061-1070 (2007). |
