(R)-AS-1

• CAT Number: I047696
• CAS Number: 2506367-95-7
• Molecular Formula: C14H16N2O3
• Molecular Weight: 260.29
• Purity: ≥95%
• IUPAC Name: (2R)-N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide
• InChI: InChI=1S/C14H16N2O3/c1-10(16-12(17)7-8-13(16)18)14(19)15-9-11-5-3-2-4-6-11/h2-6,10H,7-9H2,1H3,(H,15,19)/t10-/m1/s1
• SMILES: C[C@H](C(=O)NCC1=CC=CC=C1)N2C(=O)CCC2=O

(R)-AS-1 is a first-in-class highly selective and orally bioavailable positive allosteric modulator (PAM) of EAAT2. (R)-AS-1 is shown to have robust antiseizure properties in a broad range of epilepsy models in mice and zebrafish, as well as an excellent tolerability and safety profile in both in vitro and in vivo studies.
KEYWORDS: (R)-AS-1 | EAAT2 PAM | (R)-AS1 | (R)-AS 1 | CAS [2506367-95-7] | Glutamate | EAAT | PAM | Proteins | Antiseizure | Epilepsy | Excitatory amino acid transporter-2 | Antiseizure drug

Reference

M Abram et al. Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo. J Med Chem. 2022 Sep 8;65(17):11703-11725.