For research use only. Not for therapeutic Use.
(R)-Azasetron besylate(CAT: I040755) is the active enantiomer of azasetron, a selective 5-HT₃ receptor antagonist used primarily for its potent antiemetic effects. It works by blocking serotonin (5-hydroxytryptamine) at 5-HT₃ receptors located in the central nervous system and gastrointestinal tract, making it effective in preventing nausea and vomiting, especially those induced by chemotherapy, radiotherapy, or postoperative conditions. The (R)-enantiomer exhibits greater potency and receptor selectivity than the racemic mixture, and the besylate salt form improves its stability and solubility. (R)-Azasetron besylate is useful in both clinical settings and research focused on serotonergic signaling and gastrointestinal disorders.
| CAS Number | 2025360-91-0 |
| Synonyms | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide;benzenesulfonic acid |
| Molecular Formula | C23H26ClN3O6S |
| Purity | ≥95% |
| IUPAC Name | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide;benzenesulfonic acid |
| InChI | InChI=1S/C17H20ClN3O3.C6H6O3S/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21;7-10(8,9)6-4-2-1-3-5-6/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23);1-5H,(H,7,8,9)/t13-;/m0./s1 |
| InChIKey | GFVBDLIBPSGFDL-ZOWNYOTGSA-N |
| SMILES | CN1C(=O)COC2=C(C=C(C=C21)Cl)C(=O)NC3CN4CCC3CC4.C1=CC=C(C=C1)S(=O)(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
