(R)-Bicalutamide-d4

• CAT Number: R010125
• CAS Number: 1217826-87-3
• Molecular Formula: C18H14F4N2O4S
• Molecular Weight: 434.398
• Purity: ≥95%
• Synonyms: (2R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-d4)sulfonyl]-2-hydroxy-2-methylpropanamide; (R)-Casodex-d4
• Storage: -20°C
• IUPAC Name: (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)sulfonylpropanamide
• InChI: InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)/t17-/m0/s1/i3D,4D,6D,7D
• InChIKey: LKJPYSCBVHEWIU-FTFUYGBWSA-N
• SMILES: CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O

(R)-Bicalutamide-d4 is a deuterated form of the (R)-enantiomer of bicalutamide, a nonsteroidal anti-androgen medication used primarily in the treatment of prostate cancer. In this compound, four hydrogen atoms are replaced with deuterium, which makes it particularly useful in pharmacokinetic and metabolic studies. The deuterium labeling enhances the accuracy of tracking the drug in mass spectrometry and NMR spectroscopy. Despite the isotopic modification, (R)-Bicalutamide-d4 retains the same biological activity and therapeutic properties as the non-deuterated version, making it a valuable tool in clinical research.