For research use only. Not for therapeutic Use.
(R)-BRD3731 is a GSK3 inhibitor extracted from patent US20160375006A1, compound example 273, has IC50s of 1.05 and 6.7 μM for GSK3β and GSK3α, respectively[1].
| Catalog Number | I023666 |
| CAS Number | 2056262-08-7 |
| Synonyms | (4R)-3-(2,2-dimethylpropyl)-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one |
| Molecular Formula | C24H31N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C24H31N3O/c1-22(2,3)12-17-20-21(27-26-17)25-16-13-23(4,5)14-18(28)19(16)24(20,6)15-10-8-7-9-11-15/h7-11H,12-14H2,1-6H3,(H2,25,26,27)/t24-/m0/s1 |
| InChIKey | YZRXTIGAQRIAEX-DEOSSOPVSA-N |
| SMILES | CC1(CC2=C(C(=O)C1)C(C3=C(NN=C3N2)CC(C)(C)C)(C)C4=CC=CC=C4)C |
| Reference | [1]. Scolnick E, et, al. Uses of paralog-selective inhibitors of gsk3 kinases. US20160375006A1. |
