(R)-(-)-Camptothecin-d5

• CAT Number: R049572
• CAS Number: 1329793-44-3
• Molecular Formula: C20H16N2O4
• Molecular Weight: 353.389
• Purity: ≥95%
• Synonyms: R)-4-(Ethyl-d5)-4-hydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (R)-(-)-Camptothecine-d5; (R)-Camptothecin-d5; 20R-Camptothecin-d5
• Storage: -20°C
• IUPAC Name: (19R)-19-hydroxy-19-(1,1,2,2,2-pentadeuterioethyl)-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• InChI: InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m1/s1/i1D3,2D2
• InChIKey: VSJKWCGYPAHWDS-XNUBIDPZSA-N
• SMILES: [2H]C([2H])([2H])C([2H])([2H])[C@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

(R)-(-)-Camptothecin-d5 is a deuterated analog of camptothecin, a potent alkaloid with anticancer properties. The deuterium labeling (d5) enhances its use as a stable internal standard in mass spectrometry. Camptothecin acts as a topoisomerase I inhibitor, interfering with DNA replication and leading to cancer cell apoptosis. The (R)-(-) configuration refers to the specific chiral form of the compound, which is crucial for its biological activity. This deuterated variant is employed in pharmacokinetic studies and drug development to accurately measure camptothecin levels and analyze its effects in cancer research.