(R)-Casopitant

• CAT Number: I042322
• CAS Number: 414910-26-2
• Molecular Formula: C30H35F7N4O2
• Molecular Weight: 616.61
• Purity: ≥95%
• Synonyms: (2R,4R)-4-(4-acetylpiperazin-1-yl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide
• InChI: InChI=1S/C30H35F7N4O2/c1-18-13-24(31)5-6-26(18)27-17-25(40-11-9-39(10-12-40)20(3)42)7-8-41(27)28(43)38(4)19(2)21-14-22(29(32,33)34)16-23(15-21)30(35,36)37/h5-6,13-16,19,25,27H,7-12,17H2,1-4H3/t19-,25-,27-/m1/s1
• InChIKey: XGGTZCKQRWXCHW-DSSGHVNRSA-N
• SMILES: CC1=C(C=CC(=C1)F)[C@H]2C[C@@H](CCN2C(=O)N(C)[C@H](C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C(=O)C

(R)-Casopitant（Cat No.:I042322）is a selective neurokinin-1 (NK1) receptor antagonist used primarily for its potential to treat nausea and vomiting, particularly those associated with chemotherapy. It works by blocking substance P from binding to the NK1 receptor, which is involved in the vomiting reflex. This inhibition helps reduce the severity and frequency of nausea and vomiting in patients undergoing cancer treatments. (R)-Casopitant has also been investigated for its effects on mood disorders and pain. Ongoing research aims to further evaluate its safety, efficacy, and potential for broader therapeutic applications.