For research use only. Not for therapeutic Use.
(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4[1].
| Catalog Number | I018507 |
| CAS Number | 1593478-56-8 |
| Synonyms | (2R)-5,7-dibromo-6-fluoro-2-methyl-3,4-dihydro-2H-quinoline-1-carbaldehyde |
| Molecular Formula | C11H10Br2FNO |
| Purity | ≥95% |
| InChI | InChI=1S/C11H10Br2FNO/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3/t6-/m1/s1 |
| InChIKey | ZZLQPWXVZCPUGC-ZCFIWIBFSA-N |
| SMILES | CC1CCC2=C(C(=C(C=C2N1C=O)Br)F)Br |
| Reference | [1]. Courilleau D, et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8. |
