(R)-Colchicine

• CAT Number: R047674
• CAS Number: 75520-89-7
• Molecular Formula: C22H25NO6
• Molecular Weight: 399.443
• Purity: ≥95%
• Synonyms: (R)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; (+)-Colchicine
• Storage: -20°C
• IUPAC Name: N-[(7R)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• InChI: InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m1/s1
• InChIKey: IAKHMKGGTNLKSZ-MRXNPFEDSA-N
• SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

(R)-Colchicine (CAS 75520-89-7) is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. (R)-Colchicine stimulates the intrinsic GTPase activity of tubulin and induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Reference

1.Alkadi, Hourieh, Mohamad J. Khubeiz, and Rajwa Jbeily. "Colchicine: a review on chemical structure and clinical usage." Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious Disorders) 18.2 (2018): 105-121.