(R)-(+)-Dimethindene maleate

• CAT Number: I042972
• CAS Number: 136152-64-2
• Molecular Formula: C24H28N2O4
• Molecular Weight: 408.49
• Purity: ≥95%
• Synonyms: (Z)-but-2-enedioic acid;N,N-dimethyl-2-[3-[(1R)-1-pyridin-2-ylethyl]-1H-inden-2-yl]ethanamine
• InChI: InChI=1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1
• InChIKey: SWECWXGUJQLXJF-DASCVMRKSA-N
• SMILES: CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=CC(=O)O)C(=O)O

(R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with antihistaminic properties in pigs[1].
(R)-(+)-Dimethindene maleate possesses membrane-stabilising effect[1].
(R)-(+)-Dimethindene maleate (10 mL/kg; i.g.; once) shows antihistaminic activity with an ED50 of 2.73 mg/kg in pigs[1].

Reference

[1]. Leuschner J, et al. Evaluation of the dose-effect curves of dimethindene maleate enantiomers in various animal models. Agents and Actions, 1992, 36(2): C431-C433.