(R)-Elexacaftor

• CAT Number: I041106
• CAS Number: 2229860-99-3
• Molecular Formula: C26H34F3N7O4S
• Molecular Weight: 597.65
• Purity: ≥95%
• Synonyms: N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)pyrazol-1-yl]-2-[(4R)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide
• InChI: InChI=1S/C26H34F3N7O4S/c1-16-12-25(5,6)35(13-16)22-18(23(37)33-41(38,39)19-14-34(7)31-17(19)2)8-9-20(30-22)36-11-10-21(32-36)40-15-24(3,4)26(27,28)29/h8-11,14,16H,12-13,15H2,1-7H3,(H,33,37)/t16-/m1/s1
• InChIKey: MVRHVFSOIWFBTE-MRXNPFEDSA-N
• SMILES: C[C@@H]1CC(N(C1)C2=C(C=CC(=N2)N3C=CC(=N3)OCC(C)(C)C(F)(F)F)C(=O)NS(=O)(=O)C4=CN(N=C4C)C)(C)C

(R)-Elexacaftor（Cat No.:I041106）is a selective modulator used in combination therapies for the treatment of cystic fibrosis (CF), particularly in patients with specific mutations in the CFTR gene. It works by enhancing the function of the CFTR protein, which regulates chloride ion transport across cell membranes. (R)-Elexacaftor improves the protein’s stability and facilitates its proper folding, allowing it to reach the cell surface more effectively. This mechanism helps alleviate symptoms and improve lung function in CF patients. It is often used in combination with other drugs, like tezacaftor and ivacaftor, for optimized treatment outcomes.