For research use only. Not for therapeutic Use.
Falcarinol is a C<sub>17</sub>-polyacetylene produced by the Apiaceae family that has antimicrobial properties due to its inhibition of fatty acid biosynthesis. Falcarinol binds to the human recombinant cannabinoid (CB) receptors, CB<sub>1</sub> and CB<sub>2</sub>, (K<sub>i</sub>s = 594 and 2,100 nM, respectively) in an [ It differentially modulates synaptic and extrasynaptic GABA<sub>A</sub> receptors in a recombinant HEK293 system. <em>In vitro</em> assays of ATPase activity demonstrate that falcarinol inhibits breast cancer resistance protein ATP-binding cassette sub-family G member 2 (ABCG2; IC<sub>50</sub> = 79.3 μM), a drug efflux transporter and mediator of drug resistance. Falcarinol (6.88 μg/g feed) also inhibits aberrant crypt foci by 26.6% in azoxymethane-induced rats.
| Catalog Number | R043227 |
| CAS Number | 21852-80-2 |
| Synonyms | (3R,9Z)-1,9-Heptadecadiene-4,6-diyn-3-ol; ?(Z)-(-)-1,9-Heptadecadiene-4,6-diyn-3-ol; [R-(Z)]-1,9-Heptadecadiene-4,6-diyn-3-ol; Panaxynol; (-)-Falcarinol; (-)-Panaxynol; (cis)-(-)-3-Hydroxy-1,9-heptadecadien-4,6-diyne; Carotatoxin; Falcarinol |
| Molecular Formula | C17H24O |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Storage | -20°C |
| InChIKey | UGJAEDFOKNAMQD-QXPKXGMISA-N |
