(R)-FL118

• CAT Number: R037006
• CAS Number: 151636-76-9
• Molecular Formula: C21H16N2O6
• Molecular Weight: 392.36
• Purity: ≥95%
• Synonyms: (5R)-5-ethyl-5-hydroxy-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.02,11.04,9.015,23.017,21]tetracosa-1(13),2,4(9),14,16,21,23-heptaene-6,10-dione
• InChI: InChI=1S/C21H16N2O6/c1-2-21(26)13-5-15-18-11(7-23(15)19(24)12(13)8-27-20(21)25)3-10-4-16-17(29-9-28-16)6-14(10)22-18/h3-6,26H,2,7-9H2,1H3/t21-/m1/s1
• InChIKey: RPFYDENHBPRCTN-OAQYLSRUSA-N
• SMILES: CC[C@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=C6C(=CC5=C4)OCO6)O

(R)-FL118（Cat No.:R037006）is an investigational small molecule with potent anticancer properties. It is a derivative of flavonoid compounds and functions as a selective inhibitor of the protein translation initiation factor eIF4E. By inhibiting eIF4E, (R)-FL118 disrupts protein synthesis in cancer cells, particularly those with high eIF4E activity, and promotes cell death. This mechanism makes it a promising candidate in cancer therapy, especially for cancers resistant to traditional treatments. Research is ongoing to evaluate its efficacy, safety, and potential use in combination with other cancer therapies.