(R)-GABOB

• CAT Number: I035542
• CAS Number: 7013-07-2
• Molecular Formula: C4H9NO3
• Molecular Weight: 119.12
• Purity: 98%
• Synonyms: (R)-4-Amino-3-hydroxybutyric Acid; L-γ-Amino-β-hydroxybutyric Acid; R-(–)-γ-Amino-β-hydroxybutyric Acid; (R)-GABOB; (–)-β-Hydroxy-GABA; (R)-(–)-3-Hydroxy-GABA
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (R)-4-amino-3-hydroxybutanoic acid
• InChI: InChI=1S/C4H9NO3/c5-2-3(6)1-4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m1/s1
• InChIKey: YQGDEPYYFWUPGO-GSVOUGTGSA-N
• SMILES: OC(C[C@H](CN)O)=O

(R)-4-Amino-3-hydroxybutyric acid, also known as (R)-GABOB, is a GABA receptor modulator. It binds to GABAA and GABAB receptors and inhibits GABA uptake in rat brain synaptosomes. (R)-4-amino-3-hydroxybutyric acid is also a GABAC receptor agonist that induces currents in a patch-clamp assay using Xenopus oocytes expressing the human receptor. In vivo, (R)-4-amino-3-hydroxybutyric acid inhibits electrical discharges in the amygdala in a cat model of N-amidinobenzamide-induced seizures.

Reference

1: Candela M, Ruiz A, Feo FJ. Validation of an analysis method for 4-amino-3-hydroxybutyric acid by reversed-phase liquid chromatography. J Chromatogr A. 2000 Aug 25;890(2):273-80. doi: 10.1016/s0021-9673(00)00605-1. PMID: 11009030.