(R)-GDC-0927

• CAT Number: I040705
• CAS Number: 1642297-53-7
• Molecular Formula: C28H28FNO4
• Molecular Weight: 461.52
• Purity: ≥95%
• Synonyms: (2R)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
• InChI: InChI=1S/C28H28FNO4/c1-18-25-14-23(32)7-10-26(25)34-28(27(18)21-3-2-4-22(31)13-21)20-5-8-24(9-6-20)33-12-11-30-16-19(15-29)17-30/h2-10,13-14,19,28,31-32H,11-12,15-17H2,1H3/t28-/m1/s1
• InChIKey: KJAAPZIFCQQQKX-MUUNZHRXSA-N
• SMILES: CC1=C(C(OC2=C1C=C(C=C2)O)C3=CC=C(C=C3)OCCN4CC(C4)CF)C5=CC(=CC=C5)O

(R)-GDC-0927 ((R)-SRN-927) is a (R)-enantiomer of GDC-0927 (HY-111484)[1].

Reference

[1]. Wang L, er al. The Quest for Orally Available Selective Estrogen Receptor Degraders (SERDs). ChemMedChem. 2020 Nov 18;15(22):2072-2097.
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