(R)-HTS-3 (GLXC-25878)

• CAT Number: I047436
• CAS Number: 2771208-83-2
• Molecular Formula: C17H18F2N2O
• Molecular Weight: 304.34
• Purity: ≥95%

(R)-HTS-3 (GLXC-25878) is a potent, selective, and cell-active inhibitor of lysophosphatidylcholine acyltransferase 3 (LPCAT3) with an IC50 of 0.09 µM, an enzyme critical for synthesizing C20:4-containing phospholipids. It reduces arachidonic acid-d8 incorporation into phospholipids and mitigates RSL3-induced ferroptosis in HT-1080 and 786-O cancer cells.

Reference

[1] Reed A, et al. ACS Chem Biol. 2022 Jun 17;17(6):1607-1618.