R(+)-IAA-94

• CAT Number: I003988
• CAS Number: 54197-31-8
• Molecular Formula: C17H18Cl2O4
• Molecular Weight: 357.23
• Purity: ≥95%
• Synonyms: 2-[[(2R)-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]-acetic acid
• Target: Chloride Channels
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: 2-[[(2S)-6,7-dichloro-2-cyclopentyl-2-methyl-1-oxo-3H-inden-5-yl]oxy]acetic acid
• InChI: InChI=1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6,10H,2-5,7-8H2,1H3,(H,20,21)/t17-/m0/s1
• InChIKey: RNOJGTHBMJBOSP-KRWDZBQOSA-N
• SMILES: CC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3

R(+)-IAA-94（Cat No.:I003988）, also known as R(+)-Methylindazone, is a highly effective inhibitor of chloride channels. By blocking chloride channel activity, R(+)-IAA-94 disrupts the flow of chloride ions across cell membranes. Furthermore, it has been shown to inhibit the interaction between Nef (a protein associated with HIV) and sdAb19, a single-domain antibody. R(+)-IAA-94 binds to Nef, potentially interfering with its function. These findings suggest the potential utility of R(+)-IAA-94 as a therapeutic agent targeting chloride channels and the Nef protein.

Reference

[1]. Landry DW, et al. Epithelial chloride channel. Development of inhibitory ligands. J Gen Physiol. 1987 Dec;90(6):779-98.
[2]. Landry DW, et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244(4911):1469-72.
[3]. Weber-Schürholz S, et al. Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle. J Biol Chem. 1993 Jan 5;268(1):547-51.