(R)-Irofulven

• CAT Number: R048578
• CAS Number: 158440-71-2
• Molecular Formula: C15H18O3
• Molecular Weight: 246.30
• Purity: ≥95%
• Synonyms: (6’R)-6’-Hydroxy-3’-(hydroxymethyl)-2’,4’,6’-trimethylspiro[cyclopropane-1,5’-[5H]inden]-7’(6’H)-one; (-)-(Hydroxymethyl)acylfulvene; (-)-Irofulven; HMAF; MGI 114; NSC 683863
• Target: Apoptosis
• Storage: -20°C
• IUPAC Name: (5/'R)-5/'-hydroxy-1/'-(hydroxymethyl)-2/',5/',7/'-trimethylspiro[cyclopropane-1,6/'-indene]-4/'-one
• InChI: InChI=1S/C15H18O3/c1-8-6-10-12(11(8)7-16)9(2)15(4-5-15)14(3,18)13(10)17/h6,16,18H,4-5,7H2,1-3H3/t14-/m0/s1
• InChIKey: NICJCIQSJJKZAH-AWEZNQCLSA-N
• SMILES: CC1=C(C2=C(C3(CC3)C(C(=O)C2=C1)(C)O)C)CO

(R)-Irofulven（Cat No.:R048578）is a semi-synthetic derivative of illudin S, a natural toxin, with potent anticancer properties. It works by inducing DNA damage through alkylation, leading to DNA strand breaks and cell death, particularly in rapidly dividing cancer cells. (R)-Irofulven has shown efficacy in cancers resistant to traditional therapies, including platinum-based drugs and taxanes. Its mechanism of action also involves the generation of reactive oxygen species (ROS), enhancing its cytotoxic effects. (R)-Irofulven is being investigated for its potential in treating solid tumors, such as prostate and ovarian cancers.