For research use only. Not for therapeutic Use.
Selective 5-HT1A antagonist; less active R-(-)-enantiomer of (±)-LY426965 (Axon 1093), in comparison with its opposite (S)-(+)-enantiomer, LY 426965 (Axon 1094)
| Catalog Number | I047490 |
| CAS Number | 228418-85-7 |
| Molecular Formula | C28H38N2O2.2HCl |
| Purity | ≥95% |
| IUPAC Name | (2R)-1-cyclohexyl-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-methyl-2-phenylbutan-1-one;dihydrochloride |
| InChI | InChI=1S/C28H38N2O2.2ClH/c1-28(24-13-7-4-8-14-24,27(31)23-11-5-3-6-12-23)17-18-29-19-21-30(22-20-29)25-15-9-10-16-26(25)32-2;;/h4,7-10,13-16,23H,3,5-6,11-12,17-22H2,1-2H3;2*1H/t28-;;/m1../s1 |
| SMILES | C[C@@](CCN1CCN(CC1)C2=CC=CC=C2OC)(C3=CC=CC=C3)C(=O)C4CCCCC4.Cl.Cl |
| Reference | K Rasmussen et al. The Novel 5-Hydroxytryptamine1A Antagonist LY426965: Effects on Nicotine Withdrawal and Interactions with Fluoxetine. J. Pharmcol. Exp. Ther. 2000, 294(2), 688-700.
R. Tordera et al. Effect of different 5-HT1A receptor antagonists in combination with paroxetine on expression of the immediate–early gene Arc in rat brain. Neuropharmacol. 2003, 44, 893-902. |
