(R)-M8891

For research use only. Not for therapeutic Use.

  • CAT Number: I045315
  • CAS Number: 2575547-29-2
  • Molecular Formula: C20H17F2N3O3
  • Molecular Weight: 385.36
  • Purity: ≥95%
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(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor[1].


Catalog Number I045315
CAS Number 2575547-29-2
Synonyms

(3R)-N-[(3,5-difluorophenyl)methyl]-3-hydroxy-1-(1H-indol-5-yl)-2-oxopyrrolidine-3-carboxamide

Molecular Formula C20H17F2N3O3
Purity ≥95%
InChI InChI=1S/C20H17F2N3O3/c21-14-7-12(8-15(22)10-14)11-24-18(26)20(28)4-6-25(19(20)27)16-1-2-17-13(9-16)3-5-23-17/h1-3,5,7-10,23,28H,4,6,11H2,(H,24,26)/t20-/m1/s1
InChIKey WVGGJQVCOTYFPV-HXUWFJFHSA-N
SMILES C1CN(C(=O)C1(C(=O)NCC2=CC(=CC(=C2)F)F)O)C3=CC4=C(C=C3)NC=C4
Reference

[1]. Timo Heinrich, et al. Process for manufacturing (s)-3-hydroxy-1-(1h-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic acid 3,5-difluoro-benzylamide. WO2021001328A1.

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