(R)-MIK665

• CAT Number: I018282
• CAS Number: 1799831-02-9
• Molecular Formula: C₄₇H₄₄ClFN₆O₆S
• Molecular Weight: 875.41
• Purity: ≥95%
• Target: Bcl-2 Family
• IUPAC Name: (2R)-2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid
• InChI: InChI=1S/C47H44ClFN6O6S/c1-29-34(16-17-38(42(29)48)59-25-24-55-22-20-54(2)21-23-55)40-41-45(51-28-52-46(41)62-43(40)30-12-14-32(49)15-13-30)61-39(47(56)57)26-31-8-4-6-10-36(31)60-27-33-18-19-50-44(53-33)35-9-5-7-11-37(35)58-3/h4-19,28,39H,20-27H2,1-3H3,(H,56,57)/t39-/m1/s1
• InChIKey: PKYIMGFMRFVOMB-LDLOPFEMSA-N
• SMILES: CC1=C(C=CC(=C1Cl)OCCN2CCN(CC2)C)C3=C(SC4=NC=NC(=C34)O[C@H](CC5=CC=CC=C5OCC6=NC(=NC=C6)C7=CC=CC=C7OC)C(=O)O)C8=CC=C(C=C8)F

(R)-MIK665（Cat No.:I018282）is a selective small molecule inhibitor of the Mcl-1 protein, a member of the Bcl-2 family of anti-apoptotic proteins. Mcl-1 plays a crucial role in cell survival, particularly in cancer cells, by preventing apoptosis. By inhibiting Mcl-1, (R)-MIK665 can induce programmed cell death in cancer cells, making it a promising candidate for cancer therapy, especially in cancers that are resistant to other forms of chemotherapy. Preclinical studies have shown that (R)-MIK665 can enhance the effectiveness of other treatments, though further clinical trials are needed to evaluate its safety and efficacy in humans.

Reference

[1]. Andras Kotschy, et al. New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them. EP2886545A1.