(R)-MPH-220

• CAT Number: I040113
• Molecular Formula: C20H21N3O3S
• Molecular Weight: 383.46
• Purity: ≥95%
• Synonyms: (9R)-9-hydroxy-5-methyl-12-(4-morpholin-4-ylphenyl)-4-thia-2,12-diazatricyclo[7.3.0.03,7]dodeca-1,3(7),5-trien-8-one
• InChI: InChI=1S/C20H21N3O3S/c1-13-12-16-17(24)20(25)6-7-23(19(20)21-18(16)27-13)15-4-2-14(3-5-15)22-8-10-26-11-9-22/h2-5,12,25H,6-11H2,1H3/t20-/m0/s1
• InChIKey: KUIAFBSRBMWQQP-FQEVSTJZSA-N
• SMILES: CC1=CC2=C(S1)N=C3C(C2=O)(CCN3C4=CC=C(C=C4)N5CCOCC5)O

(R)-MPH-220 (Cat No.: I040113) is a chiral compound and a selective modulator of the dopamine transporter (DAT), commonly studied for its potential in treating neurological and psychiatric conditions, such as attention deficit hyperactivity disorder (ADHD). As an enantiomer of methylphenidate (MPH), (R)-MPH-220 is designed to specifically target and enhance dopamine reuptake inhibition in the brain. This action helps to increase dopamine levels, improving focus and attention. The compound is being investigated for its efficacy, safety, and potential therapeutic advantages over traditional treatments.

Reference

[1]. Gyimesi M, et al. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell. 2020 Oct 15;183(2):335-346.e13.
[Content Brief]