(R)-(-)-N-Desmethyl-PK 11195

• CAT Number: M102363
• CAS Number: 157809-85-3
• Molecular Formula: C20H19ClN2O
• Molecular Weight: 338.83
• Purity: ≥95%
• IUPAC Name: N-[(2R)-butan-2-yl]-1-(2-chlorophenyl)isoquinoline-3-carboxamide
• InChI: InChI=1S/C20H19ClN2O/c1-3-13(2)22-20(24)18-12-14-8-4-5-9-15(14)19(23-18)16-10-6-7-11-17(16)21/h4-13H,3H2,1-2H3,(H,22,24)/t13-/m1/s1
• SMILES: CC[C@@H](C)NC(=O)C1=CC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl

Precursor for (R)-[N-methyl-11C]PK 11195 for PET studies. Radioligand precursor of the peripheral benzodiazepine antagonist (R)-[N-methyl-11C]PK 11195. Racemic N-desmethyl-PK 11195 is available as Axon 2833.
Both peripheral benzodiazepine antagonists PK 11195 (Axon 1208) and R-(-)-PK 11195 (Axon 2785) are available from stock as well.
KEYWORDS: (R)-(-)-N-Desmethyl-PK 11195 | supplier | (R)-(-)-PK 11195 radioligand precursor | (R)-(-)-N-Desmethyl-PK11195 | (R)-(-)-N-Desmethyl-PK-11195 | CAS [157809-85-3] | GABA | GABA-A | Antagonist | Ion Channels | PET

Reference

F Shah et al. Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats. Nucl Med Biol. 1994 May;21(4):573-81.