(R)-Nicardipine-d3

• CAT Number: S000450
• Molecular Formula: C26H26D3N3O6
• Molecular Weight: 482.54
• Purity: ≥95%
• IUPAC Name: 5-O-[2-[benzyl(trideuteriomethyl)amino]ethyl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• InChI: InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3/t24-/m1/s1/i3D3
• InChIKey: ZBBHBTPTTSWHBA-OSWBUOMFSA-N
• SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC

(R)-Nicardipine-d3（Cat No.:S000450） is a deuterated form of (R)-nicardipine, where three hydrogen atoms are replaced with deuterium. This version is particularly used in research to study the drug’s pharmacokinetics and metabolic stability. (R)-Nicardipine is the R-enantiomer of nicardipine, a calcium channel blocker used primarily to treat hypertension and manage angina. It works by relaxing the muscles of the heart and blood vessels, reducing the workload on the heart. The deuterated form, (R)-Nicardipine-d3, allows for a more detailed examination of how the drug is metabolized and how its efficacy might be influenced by these metabolic pathways.