(R)-Olacaftor

• CAT Number: I042674
• CAS Number: 1899111-41-1
• Molecular Formula: C29H34FN3O4S
• Molecular Weight: 539.66
• Purity: ≥95%
• Synonyms: N-(benzenesulfonyl)-6-[3-fluoro-5-(2-methylpropoxy)phenyl]-2-[(4R)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide
• InChI: InChI=1S/C29H34FN3O4S/c1-19(2)18-37-23-14-21(13-22(30)15-23)26-12-11-25(27(31-26)33-17-20(3)16-29(33,4)5)28(34)32-38(35,36)24-9-7-6-8-10-24/h6-15,19-20H,16-18H2,1-5H3,(H,32,34)/t20-/m1/s1
• InChIKey: NHOUNZMCSIHKHJ-HXUWFJFHSA-N
• SMILES: C[C@@H]1CC(N(C1)C2=C(C=CC(=N2)C3=CC(=CC(=C3)F)OCC(C)C)C(=O)NS(=O)(=O)C4=CC=CC=C4)(C)C

(R)-Olacaftor（Cat No.:I042674）is a stereoisomer of Olacaftor, a drug used in the treatment of cystic fibrosis (CF) caused by specific mutations in the CFTR gene. Olacaftor, as a CFTR modulator, works by improving the function of the CFTR protein, which is defective in CF patients. The (R)-isomer of Olacaftor is designed to enhance its binding affinity and efficacy in promoting CFTR protein activity. It is typically used in combination with other CFTR modulators, such as Ivacaftor, to improve lung function and reduce respiratory symptoms in CF patients with specific mutations.