(R)-Omeprazole Sodium Salt

• CAT Number: R009880
• CAS Number: 161796-77-6
• Molecular Formula: C17H19N3O3S • Na
• Molecular Weight: 368.4
• Purity: ≥95%
• Synonyms: 6-Methoxy-2-[(R)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole Sodium Salt; (R)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]?-1H-benzimidazole Sodium Salt; (+)-Omeprazole Sodium Salt
• Storage: -20°C
• InChIKey: HVAJOLFRLWQQQL-GJFSDDNBSA-N

(R)-Omeprazole is the inactive isomer of omeprazole (Item No. 14880), a gastric proton-pump inhibitor. A stereoselective hydroxylation of (R)-omeprazole is mediated primarily by cytochrome P450 (CYP) 2C19, whereas CYP3A4 favors sulfoxidation of the active (S)-enantiomer (esomeprazole magnesium, Item No. 17326). (R)-Omeprazole has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 8.1 µM).